Computational Insight Into Vitamin K1 ω-Hydroxylation by Cytochrome P450 4F2

Vitamin K1 (VK1) plays an important role in the modulation of bleeding disorders. It has been reported that ω-hydroxylation on the VK1 aliphatic chain is catalyzed by cytochrome P450 4F2 (CYP4F2), an enzyme responsible for the metabolism of eicosanoids. However, the mechanism of VK1 ω-hydroxylation...

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Main Authors: Junhao Li (Author), Hongxiao Zhang (Author), Guixia Liu (Author), Yun Tang (Author), Yaoquan Tu (Author), Weihua Li (Author)
Format: Book
Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
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