Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice

• Main Authors: Benjamin A. Kugler (Author), Jared Lourie (Author), Nicolas Berger (Author), Nana Lin (Author), Paul Nguyen (Author), Edzana DosSantos (Author), Abir Ali (Author), Amira Sesay (Author), H. Grace Rosen (Author), Baby Kalemba (Author), Gregory M. Hendricks (Author), Joseph A. Houmard (Author), Hiromi Sesaki (Author), Philimon Gona (Author), Tongjian You (Author), Zhen Yan (Author), Kai Zou (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Dynamin-related protein 1 (Drp1) is the key regulator of mitochondrial fission. We and others have reported a strong correlation between enhanced Drp1 activity and impaired skeletal muscle insulin sensitivity. This study aimed to determine whether Drp1 directly regulates skeletal muscle i...