Partial skeletal muscle-specific Drp1 knockout enhances insulin sensitivity in diet-induced obese mice, but not in lean mice

• Главные авторы: Benjamin A. Kugler (Автор), Jared Lourie (Автор), Nicolas Berger (Автор), Nana Lin (Автор), Paul Nguyen (Автор), Edzana DosSantos (Автор), Abir Ali (Автор), Amira Sesay (Автор), H. Grace Rosen (Автор), Baby Kalemba (Автор), Gregory M. Hendricks (Автор), Joseph A. Houmard (Автор), Hiromi Sesaki (Автор), Philimon Gona (Автор), Tongjian You (Автор), Zhen Yan (Автор), Kai Zou (Автор)
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• Опубликовано: Elsevier, 2023-11-01T00:00:00Z.
• Предметы: article
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Objective: Dynamin-related protein 1 (Drp1) is the key regulator of mitochondrial fission. We and others have reported a strong correlation between enhanced Drp1 activity and impaired skeletal muscle insulin sensitivity. This study aimed to determine whether Drp1 directly regulates skeletal muscle i...