CD16/PD-L1 bi-specific aptamer for cancer immunotherapy through recruiting NK cells and acting as immunocheckpoint blockade

• Main Authors: Aixian Zheng (Author), Yanlin Du (Author), Yiru Wang (Author), Youshi Zheng (Author), Zhaoyu Ning (Author), Ming Wu (Author), Cuilin Zhang (Author), Da Zhang (Author), Jingfeng Liu (Author), Xiaolong Liu (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is well established that natural killer (NK) cells can be used as an alternative candidate of T cells for adoptive cell therapy (ACT) due to its high killing capacity, off-the-shelf utility, and low toxicity. Though NK cells provide rapid and potent immune effects, they still suffer from insuffic...