The effect of cocaine on gastric mucosal PGE2, LTC4 and ulcerations

• Main Authors: L. D. G. Angus (Author), T. A. Stein (Author), L. J. Auguste (Author), J. Gintautas (Author), J. Westervelt (Author), L. Wise (Author), G. W. Shaftan (Author)
• Format: Book
• Published: Hindawi Limited, 1993-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The association between cocaine use and acute gastroduodenal perforation is known. The effect of cocaine and stress on gastric mucosal ulceration and the levels of prostaglandin E2 (PGE2) and leukotriene C4 (LTC4) was studied in 40 Sprague-Dawley rats. Controls received intraperitoneal (i.p.) saline...