A structural classification of the variant surface glycoproteins of the African trypanosome.

• Main Authors: Sara Đaković (Author), Johan P Zeelen (Author), Anastasia Gkeka (Author), Monica Chandra (Author), Monique van Straaten (Author), Konstantina Foti (Author), Janet Zhong (Author), Evi P Vlachou (Author), Francisco Aresta-Branco (Author), Joseph P Verdi (Author), F Nina Papavasiliou (Author), C Erec Stebbins (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Long-term immune evasion by the African trypanosome is achieved through repetitive cycles of surface protein replacement with antigenically distinct versions of the dense Variant Surface Glycoprotein (VSG) coat. Thousands of VSG genes and pseudo-genes exist in the parasite genome that, together with...