Pentagalloylglucose reduces AGE-induced inflammation by activating Nrf2/HO-1 and inhibiting the JAK2/STAT3 pathway in mesangial cells

• Main Authors: Jinzhi Tong (Author), Jian Fang (Author), Tiantian Zhu (Author), Pan Xiang (Author), Jiaojiao Shang (Author), Lei Chen (Author), Jindong Zhao (Author), Yanxin Wang (Author), Li Tong (Author), Min Sun (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pentagalloylglucose (PGG), a gallotannin polyphenolic compound, has been found to possess a host of beneficial pharmacologic activities, such as anti-inflammatory and antioxidative activities. We previously demonstrated that PGG is capable of binding to the cell membrane of renal mesangial cells, bu...