DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway

• Main Authors: Liangyun Li (Author), Shaoxi Diao (Author), Zixiang Chen (Author), Jintong Zhang (Author), Wei Chen (Author), Tianqi Wang (Author), Xin Chen (Author), Yuxin Zhao (Author), Tao Xu (Author), Cheng Huang (Author), Jun Li (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatic fibrosis is caused by liver damage as a consequence of wound healing response. Recent studies have shown that hepatic fibrosis could be effectively reversed, partly through regression of activated hepatic stellate cells (HSCs). Transcription factor 21 (TCF21), a member of the basic helix-loo...