Docking studies of some pyrazole containing compounds in the cyclooxygenase-2 active site

• Main Authors: Savić Jelena (Author), Antonijević Marija (Author), Crevar Milkica (Author), Brborić Jasmina (Author)
• 格式: 图书
• 出版: Pharmaceutical Association of Serbia, Belgrade, Serbia, 2023-01-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Whereas nonselective nonsteroidal anti-inflammatory drugs, such as aspirin, ibuprofen and diclofenac, inhibit both cyclooxygenase-1 and cyclooxigenase-2 enzymes, selective inhibitors target cyclooxygenase-2, which is overexpressed in inflammation, but also in cancer, atherosclerosis, Alzheimer'...