Genetic Predisposition to Numerous Large Ulcerating Basal Cell Carcinomas and Response to Immune Therapy

• Hoofdauteurs: Bahar Dasgeb (Auteur), Youssefian Leila (Auteur), Amir Hossein Saeidian (Auteur), Jun Kang (Auteur), Wenyin Shi (Auteur), Elizabeth Shoenberg (Auteur), Adam Ertel (Auteur), Paolo Fortina (Auteur), Hassan Vahidnezhad (Auteur), Jouni Uitto (Auteur)
• Formaat: Boek
• Gepubliceerd in: Wolters Kluwer Health, 2021-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract. Objective:. Well-defined germ-line mutations in the PTCH1 gene are associated with syndromic multiple basal cell carcinomas (BCCs). Here, we used whole exome sequencing (WES) to identify the role of patched-1 in patients with multiple, unusually large BCCs. Methods:. A 72-year old patient...