One extraction tool for in vitro-in vivo extrapolation? SPME-based metabolomics of in vitro 2D, 3D, and in vivo mouse melanoma models

• Main Authors: Karol Jaroch (Author), Paulina Taczyńska (Author), Marta Czechowska (Author), Joanna Bogusiewicz (Author), Kamil Łuczykowski (Author), Katarzyna Burlikowska (Author), Barbara Bojko (Author)
• Format: Book
• Published: Elsevier, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Solid phase microextraction (SPME) in combination with high-resolution mass spectrometry was employed for the determination of metabolomic profile of mouse melanoma growth within in vitro 2D, in vitro 3D, and in vivo models. Such multi-model approach had never been investigated before. Due to the lo...