Identification of novel compounds inhibiting chikungunya virus-induced cell death by high throughput screening of a kinase inhibitor library.

• Main Authors: Deu John M Cruz (Author), Rafaela M Bonotto (Author), Rafael G B Gomes (Author), Camila T da Silva (Author), Juliana B Taniguchi (Author), Joo Hwan No (Author), Benoit Lombardot (Author), Olivier Schwartz (Author), Michael A E Hansen (Author), Lucio H Freitas-Junior (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chikungunya virus (CHIKV) is a mosquito-borne arthrogenic alphavirus that causes acute febrile illness in humans accompanied by joint pains and in many cases, persistent arthralgia lasting weeks to years. The re-emergence of CHIKV has resulted in numerous outbreaks in the eastern hemisphere, and thr...