Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine

• Main Authors: Rodríguez-Muñoz María (Author), de la Torre-Madrid Elena (Author), Garzón Javier (Author), Vicente-Sánchez Ana (Author), Sánchez-Blázquez Pilar (Author)
• Format: Book
• Published: SAGE Publishing, 2009-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Although the systemic administration of cannabinoids produces antinociception, their chronic use leads to analgesic tolerance as well as cross-tolerance to morphine. These effects are mediated by cannabinoids binding to peripheral, s...