Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy

• Main Authors: Yuzhen Qian (Author), Yixuan Sun (Author), Peishang Shi (Author), Xiuman Zhou (Author), Qiongqiong Zhang (Author), Qingyu Dong (Author), Shengzhe Jin (Author), Lu Qiu (Author), Xiaoshuang Niu (Author), Xiaowen Zhou (Author), Wenshan Zhao (Author), Yahong Wu (Author), Wenjie Zhai (Author), Yanfeng Gao (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aside from antibodies, peptides show great potential as immune checkpoint inhibitors (ICIs) due to several advantages, such as better tumor penetration and lower cost. Lymphocyte-activation gene 3 (LAG-3) is an immune checkpoint which can induce T cell dysfunction through interaction with its solubl...