Methionine Cycle Rewiring by Targeting miR-873-5p Modulates Ammonia Metabolism to Protect the Liver from Acetaminophen

• Main Authors: Rubén Rodríguez-Agudo (Author), Naroa Goikoetxea-Usandizaga (Author), Marina Serrano-Maciá (Author), Pablo Fernández-Tussy (Author), David Fernández-Ramos (Author), Sofía Lachiondo-Ortega (Author), Irene González-Recio (Author), Clàudia Gil-Pitarch (Author), María Mercado-Gómez (Author), Laura Morán (Author), Maider Bizkarguenaga (Author), Fernando Lopitz-Otsoa (Author), Petar Petrov (Author), Miren Bravo (Author), Sebastiaan Martijn Van Liempd (Author), Juan Manuel Falcon-Perez (Author), Amaia Zabala-Letona (Author), Arkaitz Carracedo (Author), Jose Vicente Castell (Author), Ramiro Jover (Author), Luis Alfonso Martínez-Cruz (Author), Teresa Cardoso Delgado (Author), Francisco Javier Cubero (Author), María Isabel Lucena (Author), Raúl Jesús Andrade (Author), Jon Mabe (Author), Jorge Simón (Author), María Luz Martínez-Chantar (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug-induced liver injury (DILI) development is commonly associated with acetaminophen (APAP) overdose, where glutathione scavenging leads to mitochondrial dysfunction and hepatocyte death. DILI is a severe disorder without effective late-stage treatment, since N-acetyl cysteine must be administered...