Dysregulated hepatic UDP-glucuronosyltransferases and flavonoids glucuronidation in experimental colitis

• Main Authors: Wanying Zeng (Author), Xiaojing Liu (Author), Yangyang Wu (Author), Yuting Cai (Author), Zhennan Li (Author), Fei Ye (Author), Yuanhong Sun (Author), Feng Li (Author), Huijie Xing (Author), Shuai Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glucuronidation catalyzed by UDP-glucuronosyltransferases (UGTs) is one of the most important phase II mechanisms, facilitating drug clearance via conjugation of glucuronic acid with polar groups of xenobiotics. Accumulating evidence suggests that IBDs impact drug disposition, but whether and how IB...