Tumor-Specific Monomethyl Auristatin E (MMAE) Prodrug Nanoparticles for Safe and Effective Chemotherapy

• Autori principali: Hanhee Cho (Autore), Man Kyu Shim (Autore), Yujeong Moon (Autore), Sukyung Song (Autore), Jinseong Kim (Autore), Jiwoong Choi (Autore), Jeongrae Kim (Autore), Youngjoo Lee (Autore), Jung Yeon Park (Autore), Yongju Kim (Autore), Cheol-Hee Ahn (Autore), Mi Ra Kim (Autore), Hong Yeol Yoon (Autore), Kwangmeyung Kim (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2022-10-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

A prodrug is bioreversible medication that is specifically converted to the active drugs by enzymes overexpressed in the tumor microenvironment, which can considerably reduce the chemotherapy-induced side effects. However, prodrug strategies usually have low antitumor efficacy compared to free drugs...