Mechanism Underlying the Reversal of Drug Resistance in P-Glycoprotein-Expressing Leukemia Cells by Pinoresinol and the Study of a Derivative

• Main Authors: María C. Carpinella (Author), María L. González (Author), D. Mariano A. Vera (Author), Jerónimo Laiolo (Author), Mariana B. Joray (Author), Mariana Maccioni (Author), Sara M. Palacios (Author), Gabriela Molina (Author), Priscila A. Lanza (Author), Samanta Gancedo (Author), Vivian Rumjanek (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P-glycoprotein (P-gp) is a membrane protein associated with multidrug resistance (MDR) due to its key role in mediating the traffic of chemotherapeutic drugs outside cancer cells, leading to a cellular response that hinders efforts toward successful therapy. With the aim of finding agents that circu...