Perturbation of the dimer interface of triosephosphate isomerase and its effect on Trypanosoma cruzi.

• Main Authors: Vanesa Olivares-Illana (Author), Adela Rodríguez-Romero (Author), Ingeborg Becker (Author), Miriam Berzunza (Author), Juventino García (Author), Ruy Pérez-Montfort (Author), Nallely Cabrera (Author), Francisco López-Calahorra (Author), Marieta Tuena de Gómez-Puyou (Author), Armando Gómez-Puyou (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2007-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Chagas disease affects around 18 million people in the American continent. Unfortunately, there is no satisfactory treatment for the disease. The drugs currently used are not specific and exert serious toxic effects. Thus, there is an urgent need for drugs that are eff...