The impact of genetic variability in urate transporters on oxypurinol pharmacokinetics

• Main Authors: Hailemichael Z. Hishe (Author), Sophie L. Stocker (Author), Lisa K. Stamp (Author), Nicola Dalbeth (Author), Tony R. Merriman (Author), Amanda Phipps‐Green (Author), Daniel F. B. Wright (Author)
• Format: Book
• Published: Wiley, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The genetic determinants of the allopurinol dose‐concentration relationship have not been extensively studied. We aimed to clarify what factors, including genetic variation in urate transporters, influence oxypurinol pharmacokinetics (PKs). A population PK model for oxypurinol was developed...