A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule

A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule

FLT3L-Fc is a half-life extended, effectorless Fc-fusion of the native human FLT3-ligand. In cynomolgus monkeys, treatment with FLT3L-Fc leads to a complex pharmacokinetic/pharmacodynamic (PK/PD) relationship, with observed nonlinear PK and expansion of different immune cell types across different d...

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Main Authors: Iraj Hosseini (Author), Brett Fleisher (Author), Jennifer Getz (Author), Jérémie Decalf (Author), Mandy Kwong (Author), Meric Ovacik (Author), Travis W. Bainbridge (Author), Christine Moussion (Author), Gautham K. Rao (Author), Kapil Gadkar (Author), Amrita V. Kamath (Author), Saroja Ramanujan (Author)
Format: Book
Published: MDPI AG, 2024-05-01T00:00:00Z.
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3rd Floor Main Library

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