A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule

• প্রধান লেখক: Iraj Hosseini (লেখক), Brett Fleisher (লেখক), Jennifer Getz (লেখক), Jérémie Decalf (লেখক), Mandy Kwong (লেখক), Meric Ovacik (লেখক), Travis W. Bainbridge (লেখক), Christine Moussion (লেখক), Gautham K. Rao (লেখক), Kapil Gadkar (লেখক), Amrita V. Kamath (লেখক), Saroja Ramanujan (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2024-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

FLT3L-Fc is a half-life extended, effectorless Fc-fusion of the native human FLT3-ligand. In cynomolgus monkeys, treatment with FLT3L-Fc leads to a complex pharmacokinetic/pharmacodynamic (PK/PD) relationship, with observed nonlinear PK and expansion of different immune cell types across different d...