Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin

• Main Authors: Elisa Toropainen (Author), Sara J. Fraser-Miller (Author), Dunja Novakovic (Author), Eva M. Del Amo (Author), Kati-Sisko Vellonen (Author), Marika Ruponen (Author), Tapani Viitala (Author), Ossi Korhonen (Author), Seppo Auriola (Author), Laura Hellinen (Author), Mika Reinisalo (Author), Unni Tengvall (Author), Stephanie Choi (Author), Mohammad Absar (Author), Clare Strachan (Author), Arto Urtti (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug particles in the tear fluid, but these factors are still poorly understood. We investigated seven ocular indomethacin suspensions (experiment...