Filamin A pre-mRNA editing modulates vascularization and tumor growth

• Main Authors: Mamta Jain (Author), Greeshma Manjaly (Author), Kathrin Maly (Author), Margreet R. de Vries (Author), Michael Janisiw (Author), Lisa König (Author), Anne Yaël Nossent (Author), Michael F. Jantsch (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adenosine to inosine (A to I) editing is mediated by adenosine deaminases acting on RNA (ADAR) enzymes. Inosines are interpreted as guanosines by the translational machinery. Consequently, A to I editing in mRNAs can lead to their recoding and the formation of proteins not encoded in the genome. Fil...