Modeling of Body Weight Metrics for Effective and Cost-Efficient Conventional Factor VIII Dosing in Hemophilia A Prophylaxis

• Main Authors: Alanna McEneny-King (Author), Pierre Chelle (Author), Severine Henrard (Author), Cedric Hermans (Author), Alfonso Iorio (Author), Andrea N. Edginton (Author)
• Format: Book
• Published: MDPI AG, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The total body weight-based dosing strategy currently used in the prophylactic treatment of hemophilia A may not be appropriate for all populations. The assumptions that guide weight-based dosing are not valid in overweight and obese populations, resulting in overdosing and ineffective resource util...