Modeling of Body Weight Metrics for Effective and Cost-Efficient Conventional Factor VIII Dosing in Hemophilia A Prophylaxis

• 主要な著者: Alanna McEneny-King (著者), Pierre Chelle (著者), Severine Henrard (著者), Cedric Hermans (著者), Alfonso Iorio (著者), Andrea N. Edginton (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2017-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The total body weight-based dosing strategy currently used in the prophylactic treatment of hemophilia A may not be appropriate for all populations. The assumptions that guide weight-based dosing are not valid in overweight and obese populations, resulting in overdosing and ineffective resource util...