The P2X7 Receptor 489C>T Gain of Function Polymorphism Favors HHV-6A Infection and Associates With Female Idiopathic Infertility

• Main Authors: Anna Pegoraro (Author), Daria Bortolotti (Author), Roberto Marci (Author), Elisabetta Caselli (Author), Simonetta Falzoni (Author), Elena De Marchi (Author), Francesco Di Virgilio (Author), Roberta Rizzo (Author), Elena Adinolfi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The P2X7 receptor (P2X7R) is an ATP-gated ion channel known for its proinflammatory activity. Despite its participation in host defense against pathogens, the role played in viral infections, notably those caused by herpes viruses, has been seldom studied. Here we investigated the effect of P2X7R ex...