Zoledronic acid exacerbates inflammation through M1 macrophage polarization

• Main Authors: Junya Kaneko (Author), Toshinori Okinaga (Author), Hisako Hikiji (Author), Wataru Ariyoshi (Author), Daigo Yoshiga (Author), Manabu Habu (Author), Kazuhiro Tominaga (Author), Tatsuji Nishihara (Author)
• Format: Book
• Published: BMC, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Zoledronic acid (Zol), one of the bisphosphonates, is frequently utilized for the treatment of osteoporosis and bone metastasis. However, the onset of medication-related osteonecrosis of the jaw (MRONJ) following dental treatments has become a serious issue. We reported previousl...