Glutamine supplementation improves the efficacy of miltefosine treatment for visceral leishmaniasis.

• Main Authors: Carolina Ferreira (Author), Inês Mesquita (Author), Ana Margarida Barbosa (Author), Nuno Sampaio Osório (Author), Egídio Torrado (Author), Charles-Joly Beauparlant (Author), Arnaud Droit (Author), Cristina Cunha (Author), Agostinho Carvalho (Author), Bhaskar Saha (Author), Jerôme Estaquier (Author), Ricardo Silvestre (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>The disturbance of host metabolic pathways by Leishmania parasites has crucial consequences for the activation status of immune cells and the outcome of infection. Glutamine has been described as an immunomodulatory amino acid, yet its role during Leishmania infection...