Histone deacetylase inhibition modulates histone acetylation at gene promoter regions and affects genome-wide gene transcription in Schistosoma mansoni.

• Main Authors: Letícia Anderson (Author), Monete Rajão Gomes (Author), Lucas Ferreira daSilva (Author), Adriana da Silva Andrade Pereira (Author), Marina M Mourão (Author), Christophe Romier (Author), Raymond Pierce (Author), Sergio Verjovski-Almeida (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:Schistosomiasis is a parasitic disease infecting hundreds of millions of people worldwide. Treatment depends on a single drug, praziquantel, which kills the Schistosoma spp. parasite only at the adult stage. HDAC inhibitors (HDACi) such as Trichostatin A (TSA) induce parasite mortality in...