Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT<sub>1A</sub> Serotonin Receptor Antagonists

Design, Synthesis, and Biological Evaluation of a Series of 5- and 7-Hydroxycoumarin Derivatives as 5-HT<sub>1A</sub> Serotonin Receptor Antagonists

We have designed and synthesized a series of 60 new 5- and 7-hydroxycoumarin derivatives bearing the piperazine moiety with the expected binding to 5-HT<sub>1A</sub> and 5-HT<sub>2A</sub> receptors. Molecular docking of all investigated compounds revealed subnanomolar estimat...

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Main Authors: Kinga Ostrowska (Author), Anna Leśniak (Author), Zuzanna Czarnocka (Author), Jagoda Chmiel (Author), Magdalena Bujalska-Zadrożny (Author), Bartosz Trzaskowski (Author)
Format: Book
Published: MDPI AG, 2021-02-01T00:00:00Z.
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3rd Floor Main Library

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