Application of Quercetin in the Treatment of Gastrointestinal Cancers

• Main Authors: Seyed Mohammad Ali Mirazimi (Author), Fatemeh Dashti (Author), Mohammad Tobeiha (Author), Ali Shahini (Author), Raha Jafari (Author), Mehrad Khoddami (Author), Amir Hossein Sheida (Author), Parastoo EsnaAshari (Author), Amir Hossein Aflatoonian (Author), Fateme Elikaii (Author), Melika Sadat Zakeri (Author), Michael R Hamblin (Author), Mohammad Aghajani (Author), Minoodokht Bavarsadkarimi (Author), Hamed Mirzaei (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary

Many cellular signaling pathways contribute to the regulation of cell proliferation, division, motility, and apoptosis. Deregulation of these pathways contributes to tumor cell initiation and tumor progression. Lately, significant attention has been focused on the use of natural products as a promising strategy in cancer treatment. Quercetin is a natural flavonol compound widely present in commonly consumed foods. Quercetin has shown significant inhibitory effects on tumor progression via various mechanisms of action. These include stimulating cell cycle arrest or/and apoptosis as well as its antioxidant properties. Herein, we summarize the therapeutic effects of quercetin in gastrointestinal cancers (pancreatic, gastric, colorectal, esophageal, hepatocellular, and oral).

Item Description

1663-9812
10.3389/fphar.2022.860209