Targeted delivery of doxorubicin by CSA-binding nanoparticles for choriocarcinoma treatment

• Main Authors: Baozhen Zhang (Author), Guogang Cheng (Author), Mingbin Zheng (Author), Jinyu Han (Author), Baobei Wang (Author), Mengxia Li (Author), Jie Chen (Author), Tianxia Xiao (Author), Jian Zhang (Author), Lintao Cai (Author), Shoujun Li (Author), Xiujun Fan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Gestational trophoblastic neoplasia (GTN) can result from the over-proliferation of trophoblasts. Treatment of choriocarcinoma, the most aggressive GTN, currently requires high doses of systemic chemotherapeutic agents, which result in indiscriminate drug distribution and severe toxicity. To overcom...