Disposition and Pharmacology of a GalNAc3-conjugated ASO Targeting Human Lipoprotein (a) in Mice

Triantennary N-acetyl galactosamine (GalNAc3)-conjugated antisense oligonucleotides (ASOs) have greatly improved potency via receptor-mediated uptake. In the present study, the in vivo pharmacology of a 2'-O-(2-methoxyethyl)-modified ASO conjugated with GalNAc3 (ISIS 681257) together with its u...

Full description

Saved in:
Bibliographic Details
Main Authors: Rosie Z Yu (Author), Mark J Graham (Author), Noah Post (Author), Stan Riney (Author), Thomas Zanardi (Author), Shannon Hall (Author), Jennifer Burkey (Author), Colby S Shemesh (Author), Thazha P Prakash (Author), Punit P Seth (Author), Eric E Swayze (Author), Richard S Geary (Author), Yanfeng Wang (Author), Scott Henry (Author)
Format: Book
Published: Elsevier, 2016-01-01T00:00:00Z.
Subjects:
Online Access:Connect to this object online.
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

Connect to this object online.

3rd Floor Main Library

Holdings details from 3rd Floor Main Library
Call Number: A1234.567
Copy 1 Available