Nitrogen-Containing Bisphosphonates Downregulate Cathepsin K and Upregulate Annexin V in Osteoclasts Cultured In Vitro

• Main Authors: Arturo Bautista-Carbajal (Author), Rosina Eugenia Villanueva-Arriaga (Author), Araceli Páez-Arenas (Author), Felipe Massó-Rojas (Author), Nelly Frechero Molina (Author), Salvador García-López (Author)
• Format: Book
• Published: Hindawi Limited, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction. Bisphosphonates are widely used in the treatment of osteoporosis; however, they are associated with the serious adverse event of bisphosphonate‐related osteonecrosis of the jaw (BRONJ). Aim. The aim of this study is to assess the effects of nitrogen-containing bisphosphonates (N-PHs) o...