Jietacin Derivative Inhibits TNF-α-Mediated Inflammatory Cytokines Production via Suppression of the NF-κB Pathway in Synovial Cells

• Main Authors: Kyoko Muneshige (Author), Yuki Inahashi (Author), Makoto Itakura (Author), Masato Iwatsuki (Author), Tomoyasu Hirose (Author), Gen Inoue (Author), Masashi Takaso (Author), Toshiaki Sunazuka (Author), Yoshihisa Ohashi (Author), Etsuro Ohta (Author), Kentaro Uchida (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Synovial inflammation plays a central role in joint destruction and pain in osteoarthritis (OA). The NF-κB pathway plays an important role in the inflammatory process and is activated in OA. A previous study reported that a jietacin derivative (JD), (<i>Z</i>)-2-(8-oxodec-9-yn-1-yl)-1-vi...