Jietacin Derivative Inhibits TNF-α-Mediated Inflammatory Cytokines Production via Suppression of the NF-κB Pathway in Synovial Cells

• প্রধান লেখক: Kyoko Muneshige (লেখক), Yuki Inahashi (লেখক), Makoto Itakura (লেখক), Masato Iwatsuki (লেখক), Tomoyasu Hirose (লেখক), Gen Inoue (লেখক), Masashi Takaso (লেখক), Toshiaki Sunazuka (লেখক), Yoshihisa Ohashi (লেখক), Etsuro Ohta (লেখক), Kentaro Uchida (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2022-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Synovial inflammation plays a central role in joint destruction and pain in osteoarthritis (OA). The NF-κB pathway plays an important role in the inflammatory process and is activated in OA. A previous study reported that a jietacin derivative (JD), (<i>Z</i>)-2-(8-oxodec-9-yn-1-yl)-1-vi...