Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat

• Main Authors: Camille Lagard (Author), Dominique Vodovar (Author), Lucie Chevillard (Author), Jacques Callebert (Author), Fabien Caillé (Author), Géraldine Pottier (Author), Hao Liang (Author), Patricia Risède (Author), Nicolas Tournier (Author), Bruno Mégarbane (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tramadol overdose is frequently associated with the onset of seizures, usually considered as serotonin syndrome manifestations. Recently, the serotoninergic mechanism of tramadol-attributed seizures has been questioned. This study's aim was to identify the mechanisms involved in tramadol-induce...