Investigation of the Mechanisms of Tramadol-Induced Seizures in Overdose in the Rat

• Autors principals: Camille Lagard (Autor), Dominique Vodovar (Autor), Lucie Chevillard (Autor), Jacques Callebert (Autor), Fabien Caillé (Autor), Géraldine Pottier (Autor), Hao Liang (Autor), Patricia Risède (Autor), Nicolas Tournier (Autor), Bruno Mégarbane (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2022-10-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Tramadol overdose is frequently associated with the onset of seizures, usually considered as serotonin syndrome manifestations. Recently, the serotoninergic mechanism of tramadol-attributed seizures has been questioned. This study's aim was to identify the mechanisms involved in tramadol-induce...