Benzenesulfonamide derivatives as Vibrio cholerae carbonic anhydrases inhibitors: a computational-aided insight in the structural rigidity-activity relationships

• Main Authors: Marialuigia Fantacuzzi (Author), Ilaria D'Agostino (Author), Simone Carradori (Author), Francesco Liguori (Author), Fabrizio Carta (Author), Mariangela Agamennone (Author), Andrea Angeli (Author), Filomena Sannio (Author), Jean-Denis Docquier (Author), Clemente Capasso (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vibrio cholerae causes life-threatening infections in low-income countries due to the rise of antibacterial resistance. Innovative pharmacological targets have been investigated and carbonic anhydrases (CAs, EC: 4.2.1.1) encoded by V. cholerae (VchCAs) emerged as a valuable option. Recently, we deve...