Tyrosine 7.43 is important for mu-opioid receptor downstream signaling pathways activated by fentanyl

• Main Authors: Xiangyun Tian (Author), Junjie Zhang (Author), Shaowen Wang (Author), Huan Gao (Author), Yi Sun (Author), Xiaoqian Liu (Author), Wei Fu (Author), Bo Tan (Author), Ruibin Su (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G protein-coupled receptors can signal through both G proteins and ß-arrestin2. For the µ-opioid receptor (MOR), early experimental evidence from a single study suggested that G protein signaling mediates analgesia and sedation, whereas ß-arrestin signaling mediates respiratory depression and consti...