Wild-type and pathogenic forms of ubiquilin 2 differentially modulate components of the autophagy-lysosome pathways

• Main Authors: Akiko Idera (Author), Lisa M. Sharkey (Author), Yuki Kurauchi (Author), Keiichi Kadoyama (Author), Henry L. Paulson (Author), Hiroshi Katsuki (Author), Takahiro Seki (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Missense mutations of ubiquilin 2 (UBQLN2) have been identified to cause X-linked amyotrophic lateral sclerosis (ALS). Proteasome-mediated protein degradation is reported to be impaired by ALS-associated mutations of UBQLN2. However, it remains unknown how these mutations affect autophagy-lysosome p...