Hyaluronan Inhibits Akt, Leading to Nuclear Factor-κB Down-Regulation in Lipopolysaccharide-Stimulated U937 Macrophages

Hyaluronan (HA) of high molecular weight is used in the treatment of osteoarthritis and rheumatoid arthritis by intra-articular injection. While HA has been shown to suppress nuclear factor (NF)-κB activation by proinflammatory cytokines and lipopolysaccharide (LPS), intracellular upstream events th...

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Main Author: Tadashi Yasuda (Author)
Format: Book
Published: Elsevier, 2011-01-01T00:00:00Z.
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