Expression of NORAD correlates with breast cancer aggressiveness and protects breast cancer cells from chemotherapy

• Main Authors: Catarina Alves-Vale (Author), Ana Maria Capela (Author), Carlota Tavares-Marcos (Author), Beatriz Domingues-Silva (Author), Bruno Pereira (Author), Francisco Santos (Author), Carla Pereira Gomes (Author), Guadalupe Espadas (Author), Rui Vitorino (Author), Eduard Sabidó (Author), Paula Borralho (Author), Sandrina Nóbrega-Pereira (Author), Bruno Bernardes de Jesus (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The recently discovered human lncRNA NORAD is induced after DNA damage in a p53-dependent manner. It plays a critical role in the maintenance of genomic stability through interaction with Pumilio proteins, limiting the repression of their target mRNAs. Therefore, NORAD inactivation causes chromosoma...