Dendrobium nobile Lindl. Alkaloids Decreases the Level of Intracellular β-Amyloid by Improving Impaired Autolysosomal Proteolysis in APP/PS1 Mice

• Autori principali: Jing Nie (Autore), Lin-Shan Jiang (Autore), Yu Zhang (Autore), Yong Tian (Autore), Li-Sheng Li (Autore), Yan-Liu Lu (Autore), Wen-Jin Yang (Autore), Jing-Shan Shi (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2018-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

As the major degradation pathway for long-lived proteins and organelles, macroautophagy is a decisive factor for the survival and longevity of cells. The existing evidence indicates that the disruption of substrate proteolysis in autolysosomes is the main mechanism underlying autophagy failure in Al...