Dendrobium nobile Lindl. Alkaloids Decreases the Level of Intracellular β-Amyloid by Improving Impaired Autolysosomal Proteolysis in APP/PS1 Mice

• Päätekijät: Jing Nie (Tekijä), Lin-Shan Jiang (Tekijä), Yu Zhang (Tekijä), Yong Tian (Tekijä), Li-Sheng Li (Tekijä), Yan-Liu Lu (Tekijä), Wen-Jin Yang (Tekijä), Jing-Shan Shi (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2018-12-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

As the major degradation pathway for long-lived proteins and organelles, macroautophagy is a decisive factor for the survival and longevity of cells. The existing evidence indicates that the disruption of substrate proteolysis in autolysosomes is the main mechanism underlying autophagy failure in Al...