The pharmaceutical excipient PEG400 affect the absorption of baicalein in Caco‐2 monolayer model by interacting with UDP‐glucuronosyltransferases and efflux transport proteins

• Hlavní autoři: Siyuan Cao (Autor), Min Zhang (Autor), Minyan Yuan (Autor), Dan Yang (Autor), Mei Zhao (Autor), Shuo Zhang (Autor), Pengjiao Wang (Autor), Rongping Zhang (Autor), Xiuli Gao (Autor)
• Médium: Kniha
• Vydáno: Wiley, 2022-02-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Abstract The bioavailability of drugs is often related to intestinal metabolism and transport mechanisms. In previous studies, pharmaceutical excipients were recognized as inert substances in clinical safety evaluations. However, a large number of studies have shown that pharmaceutical excipients re...