The hydroxypropyl‐β‐cyclodextrin‐minoxidil inclusion complex improves the cardiovascular and proliferative adverse effects of minoxidil in male rats: Implications in the treatment of alopecia

• Main Authors: Fatima Maqoud (Author), Nicola Zizzo (Author), Antonietta Mele (Author), Nunzio Denora (Author), Giuseppe Passantino (Author), Rosa Scala (Author), Annalisa Cutrignelli (Author), Antonella Tinelli (Author), Valentino Laquintana (Author), Flavia laForgia (Author), Sergio Fontana (Author), Massimo Franco (Author), Angela Assunta Lopedota (Author), Domenico Tricarico (Author)
• Format: Book
• Published: Wiley, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The efficacy of minoxidil (MXD) ethanolic solutions (1%‐5% w/v) in the treatment of androgenetic alopecia is limited by adverse reactions. The toxicological effects of repeated topical applications of escalating dose (0.035%‐3.5% w/v) and of single and twice daily doses (3.5% w/v) of a nove...