Rational Design of A Novel Small-Molecule HIV-1 Inactivator Targeting Both gp120 and gp41 of HIV-1

• Main Authors: Jing Pu (Author), Yu Dai (Author), Qian Wang (Author), Lu Lu (Author), Junqi Zhang (Author), Wei Xu (Author), Lan Xie (Author), Shengqi Wang (Author), Fei Yu (Author), Xiaoyang He (Author), Shibo Jiang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Virus inactivator can inactivate cell-free virions without relying on their replication cycle, potentially reducing the impact of viral infection on cells. Previously, we successfully constructed a HIV-1 protein inactivator, 2DLT, by conjugating the D1D2 region of CD4 to the fusion inhibitor T1144 v...