Loss and Recovery of Glutaredoxin 5 Is Inducible by Diet in a Murine Model of Diabesity and Mediated by Free Fatty Acids In Vitro

Loss and Recovery of Glutaredoxin 5 Is Inducible by Diet in a Murine Model of Diabesity and Mediated by Free Fatty Acids In Vitro

Free fatty acids (FFA), hyperglycemia, and inflammatory cytokines are major mediators of β-cell toxicity in type 2 diabetes mellitus, impairing mitochondrial metabolism. Glutaredoxin 5 (Glrx5) is a mitochondrial protein involved in the assembly of iron-sulfur clusters required for complexes of the r...

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Main Authors: Sebastian Friedrich Petry (Author), Axel Römer (Author), Divya Rawat (Author), Lara Brunner (Author), Nina Lerch (Author), Mengmeng Zhou (Author), Rekha Grewal (Author), Fatemeh Sharifpanah (Author), Heinrich Sauer (Author), Gunter Peter Eckert (Author), Thomas Linn (Author)
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Published: MDPI AG, 2022-04-01T00:00:00Z.
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