Characterization of microminipigs as an in vivo experimental model for cardiac safety pharmacology

• Main Authors: Suchitra Matsukura (Author), Yuji Nakamura (Author), Xin Cao (Author), Takeshi Wada (Author), Hiroko Izumi-Nakaseko (Author), Kentaro Ando (Author), Hiroshi Yamazaki (Author), Atsushi Sugiyama (Author)
• Format: Book
• Published: Elsevier, 2017-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We pharmacologically characterized microminipigs as an in vivo experimental model by assessing cardiovascular effects of pilsicainide, verapamil and E-4031, which can preferentially inhibit cardiac Na+, Ca2+ and K+ channels, respectively. Intravenous infusion of 1 mg/kg of pilsicainide (n = 4), 0.1 ...