The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens

• 主要な著者: Luke A. Wiley (著者), Ramya Rajagopal (著者), Lisa K. Dattilo (著者), David C. Beebe (著者)
• フォーマット: 図書
• 出版事項: The Company of Biologists, 2011-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

SUMMARY We previously found that lenses lacking the Acvr1 gene, which encodes a bone morphogenetic protein (BMP) receptor, had abnormal proliferation and cell death in epithelial and cortical fiber cells. We tested whether the tumor suppressor protein p53 (encoded by Trp53) affected this phenotype....