Development of siRNA-Loaded Lipid Nanoparticles Targeting Long Non-Coding RNA LINC01257 as a Novel and Safe Therapeutic Approach for t(8;21) Pediatric Acute Myeloid Leukemia

• Main Authors: Patrick Connerty (Author), Ernest Moles (Author), Charles E. de Bock (Author), Nisitha Jayatilleke (Author), Jenny L. Smith (Author), Soheil Meshinchi (Author), Chelsea Mayoh (Author), Maria Kavallaris (Author), Richard B. Lock (Author)
• Format: Book
• Published: MDPI AG, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Standard of care therapies for children with acute myeloid leukemia (AML) cause potent off-target toxicity to healthy cells, highlighting the need to develop new therapeutic approaches that are safe and specific for leukemia cells. Long non-coding RNAs (lncRNAs) are an emerging and highly attractive...