miR-182-5p and miR-183-5p Act as GDNF Mimics in Dopaminergic Midbrain Neurons

• Main Authors: Anna-Elisa Roser (Author), Lucas Caldi Gomes (Author), Rashi Halder (Author), Gaurav Jain (Author), Fabian Maass (Author), Lars Tönges (Author), Lars Tatenhorst (Author), Mathias Bähr (Author), André Fischer (Author), Paul Lingor (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is the second-most-frequent neurodegenerative disorder worldwide. One major hallmark of PD is the degeneration of dopaminergic (DA) neurons in the substantia nigra. Glial cell line-derived neurotrophic factor (GDNF) potently increases DA neuron survival in models of PD;...