Biodistribution of Intratracheal, Intranasal, and Intravenous Injections of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles in a Mouse Model for Drug Delivery Studies

• Main Authors: Anna Maria Tolomeo (Author), Gaia Zuccolotto (Author), Ricardo Malvicini (Author), Giada De Lazzari (Author), Alessandro Penna (Author), Chiara Franco (Author), Federico Caicci (Author), Fabio Magarotto (Author), Santina Quarta (Author), Michela Pozzobon (Author), Antonio Rosato (Author), Maurizio Muraca (Author), Federica Collino (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are extensively studied as therapeutic tools. Evaluation of their biodistribution is fundamental to understanding MSC-EVs' impact on target organs. In our work, MSC-EVs were initially labeled with DiR, a fluorescent lipophilic dy...