Activation of Nicotinic Acetylcholine α7 Receptor Attenuates Progression of Monocrotaline-Induced Pulmonary Hypertension in Rats by Downregulating the NLRP3 Inflammasome

• Glavni autori: Yan Deng (Autor), Sheng-Lan Guo (Autor), Bin Wei (Autor), Xing-Cui Gao (Autor), Ying-Chuan Zhou (Autor), Jia-Quan Li (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2019-02-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Background: Inflammation and altered immunity contribute to the development of pulmonary arterial hypertension (PH). The alpha 7 nicotinic acetylcholine receptor (α7nAChR) possesses anti-inflammatory activities. The current study was performed to investigate the effects of a selective α7nAChR agonis...